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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
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Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

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Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
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Drugs Affecting GI Tract Motility: Other Laxatives01:20

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Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
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Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

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Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
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Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

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Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
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Prucalopride: For functional constipation only?

M Bellini1, D Gambaccini1, G Bassotti2

  • 1Gastrointestinal Unit, Department of Gastroenterology, University of Pisa, Pisa, Italy.

Techniques in Coloproctology
|May 14, 2016
PubMed
Summary
This summary is machine-generated.

Prucalopride, a prokinetic agent for constipation, shows potential for other conditions due to its unique properties. Further research is needed to explore these alternative therapeutic uses.

Keywords:
Alternative usesConstipationPrucaloprideTreatment

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Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Prucalopride is a selective 5-HT4 receptor agonist approved for functional constipation.
  • Its intrinsic properties suggest potential beyond gastrointestinal indications.

Purpose of the Study:

  • To systematically review evidence for alternative uses of prucalopride.
  • To explore its potential in conditions outside of functional constipation.

Main Methods:

  • Systematic review of existing literature.
  • Analysis of studies investigating prucalopride's pharmacology and clinical effects.

Main Results:

  • Prucalopride exhibits high selectivity and affinity for 5-HT4 receptors.
  • Evidence suggests potential neuroprotective and other extragastrointestinal effects.

Conclusions:

  • Prucalopride's unique properties warrant investigation for broader therapeutic applications.
  • Further clinical studies are essential to validate these potential alternative uses.