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Related Concept Videos

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Related Experiment Video

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A Rapid Screening Workflow to Identify Potential Combination Therapy for GBM using Patient-Derived Glioma Stem Cells
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G9a - An Appealing Antineoplastic Target.

Wei-Lin Chen1, Hao-Peng Sun2, Dong-Dong Li3

  • 1State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.

Current Cancer Drug Targets
|May 14, 2016
PubMed
Summary
This summary is machine-generated.

G9a histone methyltransferase regulates gene expression and cell processes, impacting human diseases. This review summarizes G9a functions and inhibitors, offering insights for drug development.

Keywords:
Biological functionsG9aHistone Lysine Methltransferaseantineoplastic targetdiseasesinhibitors

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Area of Science:

  • Biochemistry
  • Epigenetics
  • Molecular Biology

Background:

  • G9a is a key histone methyltransferase involved in gene regulation.
  • It forms a complex with G9a-like protein (GLP) for in vivo activity.
  • G9a's role extends to nonhistone proteins, influencing biological processes and diseases.

Purpose of the Study:

  • To review the biological functions of G9a.
  • To summarize current knowledge on G9a inhibitors.
  • To highlight G9a's role in gene expression, cell processes, and diseases.

Main Methods:

  • Literature review of G9a functions and inhibitors.
  • Analysis of published articles and patents on G9a inhibitors.
  • Synthesis of current research status and discovery perspectives.

Main Results:

  • G9a regulates gene expression and cellular processes.
  • G9a is implicated in various human diseases.
  • Multiple classes of G9a inhibitors have been identified, with varying activities.

Conclusions:

  • G9a plays a significant role in biological functions and diseases.
  • A review of G9a inhibitors provides insights into their discovery and characterization.
  • Future research should address challenges and opportunities in G9a-targeted drug development.