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Embryonic and postnatal telomere length decrease with ovulation order within clutches.

José C Noguera1, Neil B Metcalfe1, Sophie Reichert1

  • 1Institute of Biodiversity Animal Health &Comparative Medicine, College of Medical, Veterinary &Life Sciences, Graham Kerr Building, University of Glasgow, Glasgow G12 8QQ, UK.

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Summary
This summary is machine-generated.

Telomere length (TL) in early life predicts lifespan. Ovulation order significantly impacts TL in zebra finch embryos, with later-hatched birds showing shorter telomeres, a difference that persists into adulthood.

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Area of Science:

  • Evolutionary biology
  • Genetics
  • Developmental biology

Background:

  • Telomere length (TL) in early life is a predictor of lifespan.
  • Parental factors and environment influence individual TL variation.
  • The impact of ovulation order on TL has not been previously studied.

Purpose of the Study:

  • To investigate the effect of ovulation order on TL in zebra finch embryos and adults.
  • To determine if TL differences due to ovulation order are maintained into adulthood.

Main Methods:

  • Examined within- and across-clutch effects of ovulation order on TL in zebra finch embryos (N=151) under controlled incubation.
  • Assessed whether ovulation order effects on TL persisted in adult zebra finches (N=122).

Main Results:

  • Embryonic TL significantly decreased with within-clutch ovulation order, irrespective of clutch and egg size.
  • The TL difference between first and last-laid embryos was comparable to average telomere loss during development.
  • This effect was observed within clutches but not across them, and remained evident in adults.

Conclusions:

  • Ovulation order is a significant factor influencing early-life TL in zebra finches.
  • Parental effects on TL, mediated by ovulation order, may contribute to the poorer performance of later-offspring.
  • Early-life TL, influenced by ovulation order, could have long-term implications for lifespan and fitness.