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Updated: Mar 21, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

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Relationship between pregnancy experience and the development of certain neuropsychiatric disorders in childhood

Abraham M Lilienfeld, Benjamin Pasamanick, Martha Rogers

    International Journal of Epidemiology
    |May 14, 2016
    PubMed

    Insights

    Reproductive causality links fetal deaths, including abortion and stillbirth, to a spectrum of brain damage seen in neuropsychiatric disorders. This continuum has significant public health research and administrative implications.

    Area of Science:

    • Reproductive epidemiology
    • Neuroscience
    • Public health

    Background:

    • Reproductive health outcomes are critical indicators of population well-being.
    • Neuropsychiatric disorders represent a significant global health burden.
    • Understanding the causal pathways from reproductive events to later-life health is essential.

    Purpose of the Study:

    • To postulate a continuum of reproductive causality.
    • To link fetal deaths (abortion, stillbirth, neonatal) to brain damage.
    • To discuss public health implications of this continuum.

    Main Methods:

    • Conceptual framework development.
    • Literature synthesis.
    • Postulation of a causal continuum.

    Main Results:

    • A gradient of reproductive causality is proposed, connecting fetal death to brain damage.
    • This continuum suggests a link between early reproductive events and later neuropsychiatric conditions.
    • The findings highlight potential shared etiological factors.

    Conclusions:

    • The postulated continuum offers a novel perspective on reproductive health and neurodevelopment.
    • Research and public health administration should consider this continuum for prevention and intervention strategies.
    • Further investigation is warranted to validate the proposed causal links.

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