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Complex formation between metronidazole and sodium urate: effect on photodegradation of metronidazole
1College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee 32307.
Pharmaceutical Research
|January 1, 1989
Abstract:
Photodegradation of solutions of metronidazole in the presence and absence of sodium urate was studied. Photodegradation appeared to follow zero-order kinetics and was found to be dependent on the pH, buffer species, sodium urate concentration, and light source. Complex formation between metronidazole and sodium urate accounted for the photostabilization of metronidazole. The dissociation constant for this complex was calculated to be 3.4 x 10(-3) M.