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Subretinal Bone Formation in a Patient with Giant Cell Tumor of the Sphenoid
Christopher K Hwang1, George Baker Hubbard1, Louis Rapkin2
1Department of Ophthalmology, Emory University School of Medicine, Atlanta, Ga., USA.
Background/Aims:
To report a case of subretinal bone formation after the treatment with denosumab for a giant cell tumor of the sphenoid, which had recurred after surgical resection.
Methods:
The clinical history and fundus findings including imaging, histologic and immunohistochemical features of the primary tumor and subretinal lesion were reviewed.
Results:
A 14-year-old boy was evaluated for a suprasellar mass. Resection of the lesion showed giant cell tumor of bone (GCT). An MRI study at the 1-month follow-up appointment showed tumor progression, and denosumab was initiated. Two months after the initial presentation, the patient developed a worsening scotoma of the right eye. Dilated fundus examination showed a yellow-tan-colored subretinal mass temporal to the fovea. The subretinal lesion was removed and showed lamellar bone with associated fibrocellular tissue.
Conclusion:
Denosumab therapy for GCT of the sphenoid may be associated with subretinal bone formation.
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