Related Experiment Video
Updated: Mar 21, 2026

Production of Nanofibrillar Patterned Collagen for Tissue Engineering
Published on: September 20, 2024
Attachment and conformational changes of collagen on bioactive glass surface
1Faculty of Physics & Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, 400084 Cluj-Napoca, Romania.
Abstract:
The proteins adsorption on biomaterials surface leads to changes in their structural conformation that may further influence the adhesion, migration and growth of cells. The aim of this study was to examine the attachment of collagen (calf skin type I) on bioactive glass powders and the conformational changes of the protein. Scanning electron microscopy analysis and X-ray photoelectron spectroscopy measurements indicate that the collagen cover the glass surface in a nanometric thin layer. The infrared amide I absorption signal shows pronounced changes in the secondary structure of the adsorbed collagen.
Related Concept Videos
Fibril-associated Collagen
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...
Type IV Collagen of Basal Lamina
A type IV collagen molecule has six alpha chains which can...

