[Dynamics of lipid peroxidation in patients with noninsulin-dependent diabetes mellitus]

The time course of erythrocytic lipid peroxidation (LP) was studied in 55 patients with insulin independent diabetes mellitus aged 40 to 60 years LP was assessed by the content of malonic dialdehyde (MDA) and peroxidative hemolysis of erythrocytes (PHE). During diabetic decompensation LP activity was increased, especially in the presence of lower limb angiopathies. The authors assumed an idea of the involvement of LP products in the pathogenesis of vascular lesions. Diabetic compensation did not cause normalization of LP activity however the use of antioxidant (alpha-tocopherol acetate) led to a significant decrease in LP activity which can be of importance for the treatment of the early stages of diabetic angiopathies.