[Binding of glucocorticoids and glucocorticoid-receptor complexes with rat liver nuclear matrix]

Studies on binding glucocorticoids and cytosol glucocorticoid-receptor complexes with rat liver nuclear matrix were conducted. Zones of binding 3H-dexamethasone and 3H-dexamethasone-receptor complexes, characterized by saturability and high affinity, were found in nuclear matrix structures. A lower level of binding was noted during incubation of nuclear matrix and cytosol from the liver of rats aged 24 mos. than in the use of the same subcellular fractions isolated from the liver of rats aged 6 mos.