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Isolated ACTH deficiency in a patient with empty sella as revealed by severe hyponatremia
Nicoleta Alina Doroftei1, Catherine de Rudder1, Nathalie de Visscher1
1a Department of Internal Medicine , Grand Hopital de Charleroi , Charleroi , Belgium.
Abstract:
Hyponatremia due to isolated adrenocorticotropic hormone (ACTH) deficiency is difficult to diagnose as it is usually indistinguishable from non-endocrine syndrome of inappropriate antidiuretic hormone secretion (SIADH). We present a case secondary to empty sella. Most patients with empty sella remain asymptomatic throughout life and require no treatment; however, in cases involving the development of isolated ACTH deficiency, corticosteroid treatment should be enforced to avoid fatal consequences.
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