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Updated: Mar 21, 2026
MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
Small non-coding RNA biomarkers in sputum for lung cancer diagnosis
Yun Su1, Maria A Guarnera2, HongBin Fang3
1Department of Surgery, Jiangsu Province Hospital, Nanjing University of Chinese Medicine, 155 Hanzhong Rd., Nanjing, 210029, China.
Abstract:
The early detection of lung cancer can reduce the mortality. However, there is no effective means in clinical settings for noninvasively detecting lung cancer. We previously developed 3 sputum miRNA biomarkers and 2 sputum small nucleolar RNA (snoRNA) biomarkers that can potentially be used for noninvasively diagnosing lung cancer. Here we evaluate the individual and combined applications of the two types of biomarkers in different sets of lung cancer patients and controls. Combined analysis of the miRNAs and snoRNAs has a synergistic effect with 89 % sensitivity and 89 % specificity, and may provide a useful tool for lung cancer early detection.
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02:39lncRNA - Long Non-coding RNAs
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