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Is the MARS questionnaire a reliable measure of medication adherence in childhood asthma?

Patricia W Garcia-Marcos1,2, Paul L P Brand2,3, Adrian A Kaptein4

  • 1a Deparment of General Pediatrics, Arrixaca University Children's Hospital , University of Murcia , Murcia , Spain.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|May 14, 2016
PubMed

Insights

The Medication Adherence Report Scale (MARS-5) shows poor accuracy for measuring medication adherence in children with asthma. This self-report tool is unreliable for both clinical practice and research settings.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Pharmacy
  • Health Outcomes Research

Background:

  • Medication adherence is crucial for managing persistent asthma in children.
  • Accurate assessment tools are needed for clinical practice and research.
  • The Medication Adherence Report Scale (MARS-5) is a self-report measure for adherence.

Purpose of the Study:

  • To evaluate the reliability of the Medication Adherence Report Scale (MARS-5) for assessing adherence in children with persistent asthma.
  • To compare MARS-5 scores with electronically measured adherence rates.

Main Methods:

  • A prospective cohort study followed children (2-13 years) with persistent asthma for one year.
  • Electronically measured adherence to inhaled corticosteroids (ICS) was tracked.
  • Spearman's rank correlation and ROC curve analysis assessed the relationship between MARS-5 scores and electronic adherence.

Main Results:

  • High MARS-5 scores were reported (median 24).
  • A significant correlation existed between MARS-5 and electronic adherence (rho=0.47, p<0.0001), but with considerable variation.
  • The MARS-5 score of ≥23 had limited predictive ability (LR+ 1.65, LR- 0.27).

Conclusions:

  • The MARS-5 self-report scale is too inaccurate for reliable adherence assessment in pediatric asthma.
  • Findings suggest the MARS-5 is not a suitable tool for clinical practice or research in this population.
Abstract

Keywords:
MARS-5adherenceasthmachildrenelectronic monitoringinhaled corticosteroids

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