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mTOR: An attractive therapeutic target for osteosarcoma?

Liu Ding1, Liu Congwei1, Qing Bei2

  • 1Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.

Oncotarget
|May 14, 2016
PubMed

Insights

Targeting the mammalian target of rapamycin (mTOR) pathway shows promise for treating osteosarcoma (OS). This review explores mTOR

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Osteosarcoma (OS) is a prevalent bone cancer in young individuals, characterized by poor prognosis and chemotherapy resistance.
  • The mammalian target of rapamycin (mTOR) pathway is frequently activated in OS, promoting tumor growth and metastasis.

Purpose of the Study:

  • To review the role of the mTOR pathway in osteosarcoma.
  • To summarize the current research on mTOR inhibitors for OS treatment.
  • To explore combination therapies involving mTOR inhibitors for improved OS management.

Main Methods:

  • Literature review of studies on mTOR signaling in osteosarcoma.
  • Analysis of preclinical and clinical research on mTOR inhibitors in OS.
  • Discussion of potential combination strategies with mTOR inhibitors.

Main Results:

  • mTOR pathway activation is a key driver of OS progression.
  • mTOR inhibitors demonstrate potential as targeted therapies for OS.
  • Combination therapies may overcome resistance and enhance treatment efficacy.

Conclusions:

  • Targeting the mTOR pathway represents a promising therapeutic strategy for osteosarcoma.
  • Further research into mTOR inhibitors and combination therapies is warranted to improve patient outcomes.
Keywords:
apoptosisautophagymTORosteosarcomatarget

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