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MMP3 -1171 5A/6A Promoter Genotype Influences Serum MMP3 Levels and Is Associated with Deep Venous Thrombosis

Xiang-Ping Li1, Guang-Zhen Wan2, Guang-Jian Wang3

  • 1Department of Emergency Orthopedics, Linyi People's Hospital of Shandong Province, Linyi, Shandong, P.R. China.

Annals of Vascular Surgery
|May 15, 2016
PubMed
Abstract

Insights

Matrix metalloproteinase-3 (MMP3) gene polymorphism and increased protein expression are linked to a higher risk of deep venous thrombosis (DVT) in the Chinese Han population. The 6A allele of MMP3 -1171 5A>6A may increase DVT susceptibility.

Area of Science:

  • Genetics
  • Molecular Biology
  • Vascular Medicine

Background:

  • Deep venous thrombosis (DVT) is a significant vascular condition.
  • The role of matrix metalloproteinase-3 (MMP3) in DVT pathogenesis requires further investigation.
  • Genetic variations and protein expression levels of MMP3 may influence DVT risk.

Purpose of the Study:

  • To examine the association between MMP3 gene polymorphism (-1171 5A>6A) and protein expression with DVT in the Chinese Han population.
  • To determine if specific MMP3 genotypes or alleles correlate with an increased risk of developing DVT.
  • To assess MMP3 serum levels in DVT patients compared to healthy controls.

Main Methods:

  • Genotyping of the MMP3 -1171 5A>6A promoter polymorphism using polymerase chain reaction-restriction fragment length polymorphism.
  • Quantification of MMP3 serum levels via enzyme-linked immunosorbent assay.
  • Statistical analysis of genotype frequencies, allele frequencies, and serum protein levels in 280 subjects (144 DVT patients, 136 controls).

Main Results:

  • Significant differences in MMP3 -1171 5A>6A genotype frequencies were observed between DVT patients and controls (P < 0.05).
  • The 6A allele of MMP3 -1171 5A>6A was associated with an elevated risk of DVT (OR = 1.961, P < 0.01).
  • MMP3 serum levels were significantly higher in DVT patients compared to controls (P < 0.05), particularly in those with 5A/6A and 6A/6A genotypes.

Conclusions:

  • MMP3 gene -1171 5A>6A polymorphism is associated with DVT risk in the Chinese Han population.
  • Upregulated MMP3 protein expression may play a role in the development of DVT.
  • These findings suggest MMP3 as a potential genetic and molecular marker for DVT risk assessment.

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