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The development of pulmonary surfactant lipids in a neonatal marsupial and the rat
K A Ribbons1, R V Baudinette, E J McMurchie
1School of Biological Sciences, Flinders University of South Australia, Bedford Park.
Abstract:
The composition of pulmonary surfactant during development was compared in a marsupial, the tammar wallaby, and the rat. For both species phospholipid fatty acid and neutral lipid fatty acid composition is similar, and phosphatidylcholine was the principal phospholipid at each age group. The relative amount of each phospholipid class significantly changed with time in both species but the extent of these changes did not vary between species. The neutral lipid component of surfactant varied significantly between the marsupial and eutherian, with higher levels of free cholesterol observed in the former. Overall the lipid composition of pulmonary surfactant in the developing wallaby is similar to that seen in eutherians with the exception being the level of free cholesterol.