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Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

Defense Mechanism Against Infection

Defense Mechanism Against Infection

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Fungal Phylum Microsporidia

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Related Experiment Video

Updated: Mar 21, 2026

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

Skin Immunity to Candida albicans.

Sakeen W Kashem¹, Daniel H Kaplan²

¹Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.

Trends in Immunology

|May 15, 2016

Summary

Candida albicans, a common fungus, can cause infections like candidiasis. This review focuses on skin immunity against this opportunistic pathogen, exploring cellular pathways in humans and mice.

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Area of Science:

Immunology
Mycology
Dermatology

Background:

Candida albicans is a fungus that normally lives on the skin but can cause opportunistic infections.
Infections range from superficial to disseminated candidiasis, including chronic mucocutaneous candidiasis (CMC).
Immune responses vary by infection site, indicating tissue-specific immunity.

Purpose of the Study:

To review cellular pathways involved in skin immunity against Candida albicans.
To highlight insights from human and mouse skin infection models.
To understand host-pathogen interactions in cutaneous candidiasis.

Main Methods:

Review of established and emerging research on cutaneous antifungal immunity.
Analysis of genetic studies in chronic mucocutaneous candidiasis (CMC) patients.
Comparative examination of human and mouse skin models.

Main Results:

Host genetics reveal conserved pathways for immune recognition of C. albicans.
Tissue compartmentalization influences immune responses to C. albicans.
Specific cellular pathways are crucial for promoting skin antifungal immunity.

Conclusions:

Cutaneous immunity against Candida albicans involves complex, site-specific cellular pathways.
Understanding these pathways is key to combating opportunistic fungal skin infections.
Further research in human and mouse models will elucidate antifungal defense mechanisms.