Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

2.0K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activation of the auricular vagus nerve reflex suppresses airway inflammation.

Immunity·2026
Same author

IL-13 signaling in cDC2 is required for systemic anaphylactic responses.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Induction of human pruriceptors from pluripotent stem cells via transcription factors.

Stem cell reports·2026
Same author

The evolving understanding of prurigo nodularis.

Clinical and experimental dermatology·2026
Same author

Restoring balance in atopic disorders: insights into type 2 immunity and chronic inflammation.

Frontiers in immunology·2026
Same author

Neuronal responses to cytokines limit intestinal hypermotility and systemic effects of colonic inflammation.

iScience·2026

Related Experiment Video

Updated: Mar 21, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.8K

New insights into basophil heterogeneity.

Landon K Oetjen1,2,3, Mario Noti4, Brian S Kim5,6,7,8,9

  • 1Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8123, St. Louis, MO, 63110, USA.

Seminars in Immunopathology
|May 15, 2016
PubMed
Summary

Basophil heterogeneity is key to understanding immunity and inflammation. New insights into these diverse innate immune cells can guide disease treatment and drug development.

More Related Videos

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

34.3K
The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity
08:26

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

Published on: December 14, 2016

16.1K

Related Experiment Videos

Last Updated: Mar 21, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.8K
Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

34.3K
The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity
08:26

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

Published on: December 14, 2016

16.1K

Area of Science:

  • Immunology
  • Cell Biology
  • Pathogenesis

Background:

  • Basophils are innate immune cells crucial for antihelminth immunity and barrier inflammation.
  • Recent research reveals significant, previously unrecognized heterogeneity within basophil populations.
  • The functional and regulatory diversity of basophils and its impact on human diseases are not well understood.

Purpose of the Study:

  • To review and highlight the importance of basophil heterogeneity.
  • To connect basophil diversity to human disease pathogenesis.
  • To inform the development of novel therapeutic strategies targeting basophils.

Main Methods:

  • Literature review of recent discoveries in basophil research.
  • Analysis of emerging data on basophil heterogeneity.
  • Synthesis of current knowledge on basophil function in disease.

Main Results:

  • Basophil populations exhibit significant functional and regulatory diversity.
  • This heterogeneity plays a critical role in various disease processes.
  • Understanding basophil diversity offers new avenues for therapeutic intervention.

Conclusions:

  • Insights into basophil heterogeneity are essential for advancing our understanding of immune responses.
  • Targeting specific basophil subsets may lead to more effective treatments for inflammatory and immune-mediated diseases.
  • Further research into basophil diversity will unlock new therapeutic potentials.