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Updated: Mar 21, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
New insights into basophil heterogeneity
Landon K Oetjen1,2,3, Mario Noti4, Brian S Kim5,6,7,8,9
1Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8123, St. Louis, MO, 63110, USA.
Abstract:
Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.
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