Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

2.3K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.3K
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

2.2K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
2.2K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

1.5K
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
1.5K
Allergic Reactions02:06

Allergic Reactions

33.4K
Overview
33.4K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

142
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
142

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report.

Allergy·2026
Same author

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis.

Cell host & microbe·2026
Same author

L-Phenylalanine is a metabolic checkpoint of human Th2 cells.

Cell reports. Medicine·2025
Same author

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis.

bioRxiv : the preprint server for biology·2025
Same author

Author Correction: Production and use of antigen tetramers to study antigen-specific B cells.

Nature protocols·2024
Same author

Correction: Pru p 9, a new allergen eliciting respiratory symptoms in subjects sensitized to peach tree pollen.

PloS one·2024

Related Experiment Video

Updated: Mar 21, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

4.0K

Allergen-Associated Immunomodulators: Modifying Allergy Outcome.

Cristina Gómez-Casado1, Araceli Díaz-Perales2

  • 1Centre for Plant Biotechnology and Genetics (UPM-INIA), Technical University of Madrid, Madrid, Spain. cristina.gomez_casado@med.lu.se.

Archivum Immunologiae Et Therapiae Experimentalis
|May 15, 2016
PubMed
Summary

Allergies are rising, but causes remain unclear. This review explores how non-protein molecules accompanying allergens, like those in pollen, can influence allergic responses, offering new insights for prevention and treatment.

Keywords:
AllergenCarbohydratesImmunomodulatorLPSLipidsParticles

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.7K
Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

620

Related Experiment Videos

Last Updated: Mar 21, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

4.0K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.7K
Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

620

Area of Science:

  • Immunology
  • Allergology
  • Molecular Biology

Background:

  • Rising global allergy prevalence since the mid-20th century.
  • Traditional focus on protein structure for allergenicity is insufficient.
  • Allergens exist in complex biological mixtures, not as isolated molecules.

Purpose of the Study:

  • To review the role of non-protein molecules in modulating allergic responses.
  • To highlight how allergen-associated molecules influence immune regulation.
  • To provide a basis for understanding and potentially preventing allergies.

Main Methods:

  • Literature review of studies on allergen-associated molecules.
  • Analysis of immune-regulatory properties of non-protein components.
  • Examination of examples from pollen and food allergens.

Main Results:

  • Non-protein molecules accompanying allergens can significantly modulate immune responses.
  • These molecules can either enhance or suppress allergic reactions.
  • Understanding these interactions is crucial for a comprehensive view of allergenicity.

Conclusions:

  • Allergenicity is influenced by more than just protein structure.
  • Non-protein components play a key role in the immune response to allergens.
  • Further research into these interactions may lead to novel therapeutic strategies.