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Impacts can be classified in various forms, primarily under two subgroups: central impact and oblique impact. A central impact occurs when two objects collide head-on, possessing opposite velocities aligned along the line of impact. Conversely, an oblique impact occurs when two objects collide at an angle, resulting in a modification of both direction and velocity.
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Human behavior is intricately shaped by social influences that arise from interactions with others in diverse contexts. These influences not only mold beliefs and attitudes but also drive the regulation of behaviors through both direct communication and observational learning. The study of these processes falls within the domain of social psychology, which seeks to understand how individuals are affected by and affect those around them.Mechanisms of Social InfluenceDirect social influence...
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Impact01:30

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Impact occurs when two bodies collide, leading to the application of impulsive forces between them. Analyzing impact mechanics involves considering two colliding particles moving along a line known as the line of impact, which passes through their centers and is perpendicular to the contact plane.
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Impact of Individuals on a Group01:25

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Related Experiment Video

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Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
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ASCO Plenary Sessions: impact, legacy, future.

Andrae Vandross1, Vinay Prasad2, Sham Mailankody3

  • 1Division of Hematology Oncology, University of California Los Angeles, Los Angeles, CA.

Seminars in Oncology
|May 15, 2016
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Summary
This summary is machine-generated.

ASCO Plenary sessions highlight practice-changing cancer treatments like ALK inhibitors and checkpoint inhibitors, but some initially promising therapies ultimately falter. Negative trials, though rare, are crucial, and industry funding significantly influences abstract selection.

Keywords:
ASCOBreaking abstractInfluenceMedical conferencesPlenary Sessions

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Area of Science:

  • Oncology
  • Clinical Trial Analysis
  • Medical Conferences

Background:

  • The American Society of Clinical Oncology (ASCO) annual meeting features a Plenary session showcasing impactful research.
  • Plenary abstracts are often published concurrently in high-impact journals like The New England Journal of Medicine and The Lancet.
  • Industry sponsorship plays a significant role in the selection and presentation of abstracts.

Purpose of the Study:

  • To analyze trends and themes in ASCO Plenary sessions over a nine-year period.
  • To evaluate the long-term impact and practice-changing potential of selected oncology abstracts.
  • To understand the role of industry influence in high-profile oncology research presentations.

Main Methods:

  • Review of abstracts presented at ASCO Plenary sessions over nine years.
  • Categorization of abstracts based on their impact on clinical practice (practice-changing, faltered, negative trials).
  • Analysis of industry sponsorship data for Plenary abstracts.

Main Results:

  • Many selected topics, such as ALK inhibitors for NSCLC and checkpoint inhibitors for melanoma, proved practice-changing.
  • Some initially promising therapies, including Cetuximab for NSCLC and Bevacizumab for renal cell cancer, did not ultimately alter standard practice.
  • Negative trials, while infrequent, were highly significant, impacting treatment guidance for ovarian cancer and HER2+ breast cancer, and showing no benefit for upfront Bevacizumab in glioblastoma.
  • Industry sponsored 62% of the analyzed Plenary abstracts.

Conclusions:

  • ASCO Plenary sessions represent a conservative selection of abstracts believed to be influential at the time of presentation.
  • The ultimate impact of presented research on oncology practice evolves over time, with some abstracts succeeding and others faltering.
  • Reviewing Plenary sessions offers insights into the evolving landscape, influence, and future direction of cancer care.