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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Soft tissue sarcomas in skin: presentations and management.

Joshua C Patt1, Nikkole Haines2

  • 1Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, NC; Levine Cancer Institute, Charlotte, NC.

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|May 15, 2016
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Soft tissue sarcomas are rare malignant tumors. A systematic approach, including surgery, chemotherapy, and radiation therapy, managed by a multidisciplinary team, is crucial for optimal outcomes.

Keywords:
Cutaneous malignancyDermal manifestationsSarcoma

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Area of Science:

  • Oncology
  • Surgical Pathology
  • Dermatology

Background:

  • Soft tissue sarcomas are rare, heterogeneous malignant tumors.
  • Most originate deep to the integumentary layer, with few arising from dermal layers.
  • A systematic evaluation is essential to prevent misdiagnosis and inappropriate management.

Purpose of the Study:

  • To outline general principles and treatment strategies for soft tissue sarcomas.
  • To review common cutaneous manifestations of sarcoma.
  • To emphasize the importance of a systematic approach in managing these neoplasms.

Main Methods:

  • Systematic evaluation and staging of soft tissue sarcomas.
  • Primary management with en-bloc surgical resection.
  • Utilization of adjuvant therapies including chemotherapy and radiation therapy.

Main Results:

  • En-bloc surgical resection is the primary treatment modality post-staging.
  • Chemotherapy and radiation therapy are common adjuvant treatments.
  • Multidisciplinary team care is vital for optimal patient outcomes.

Conclusions:

  • A systematic approach to evaluation and workup prevents management errors.
  • Multidisciplinary care ensures optimal outcomes for soft tissue sarcoma patients.
  • Understanding cutaneous manifestations aids in diagnosis and management.