Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fetal neural development and schizophrenia.

M Lyon1, C E Barr, T D Cannon

  • 1Social Science Research Institute, USC, Los Angeles 90089-1111.

Schizophrenia Bulletin
|January 1, 1989
PubMed
Summary

Schizophrenia risk is linked to fetal development issues, including brain abnormalities and dopamine transmission problems. Genetic and environmental factors likely combine to cause psychosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Practices and perspectives on advanced diagnostic and interventional bronchoscopy among pediatric pulmonologists in the United States.

Pediatric pulmonology·2024
Same author

Lithophagy Prolongs Voluntary Dives in American alligators (<i>Alligator mississippiensis</i>).

Integrative organismal biology (Oxford, England)·2021
Same author

Impact of socio-economic deprivation on endometrial cancer survival in the North West of England: a prospective database analysis.

BJOG : an international journal of obstetrics and gynaecology·2020
Same author

Polyvagal theory, neurodevelopment and psychiatric disorders.

Irish journal of psychological medicine·2018
Same author

Anomalous left coronary artery from the pulmonary artery (ALCAPA) diagnosed in adulthood: Varied clinical presentation, therapeutic approach and outcome.

International journal of cardiology·2018
Same author

Reliability of the sliding scale for collecting affective responses to words.

Behavior research methods·2018

Area of Science:

  • Neuroscience
  • Psychiatry
  • Developmental Biology

Background:

  • Schizophrenia is a complex psychiatric disorder with suspected developmental origins.
  • Understanding early life factors is crucial for identifying schizophrenia's etiological underpinnings.

Purpose of the Study:

  • To explore factors of potential etiological significance in fetal development related to schizophrenia.
  • To integrate findings from various disciplines investigating schizophrenia's causes.

Main Methods:

  • Conference proceedings synthesizing research on brain imaging, neuropathology, neurochemistry, genetics, and neurobehavior.
  • Review of correlations between prenatal factors and schizophrenia incidence.

Main Results:

  • Evidence suggests dysfunction in specific brain regions: frontal/parieto-occipital neocortex, basal ganglia, hippocampus, and amygdala.
  • Dopamine transmission implicated in basal ganglia and neocortical disturbances.
  • Prenatal factors like viral infection, stress, obstetrical complications, and minor physical anomalies correlate with schizophrenia.
  • Autonomic nonresponding, birth complications, and ventricular enlargement linked to negative symptoms in high-risk populations.

Conclusions:

  • A dual factor model is proposed, integrating genetic and environmental influences for psychosis development.
  • Fetal neural development disruptions are significant contributors to schizophrenia etiology.

Related Experiment Videos