Related Experiment Videos
Calicheamicin gamma 1I and DNA: molecular recognition process responsible for site-specificity
N Zein1, M Poncin, R Nilakantan
1Cyanamid Company, Medical Research Division, Lederle Laboratories, Pearl River, NY 10965.
Science (New York, N.Y.)
|May 12, 1989
Abstract:
Calicheamicin gamma 1I is a recently discovered diyne-ene-containing antitumor antibiotic that cleaves DNA in a double-stranded fashion, a rarity among drugs, at specific sequences. It is proposed that the cutting specificity is due to a combination of the complementarity of the diyne-ene portion of the aglycone with DNA secondary structures and stabilization by association of the thiobenzoate-carbohydrate tail with the minor groove.