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Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

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Time-programmed release of fluoroscein isocyanate dextran from micro-pattern-designed polymer scrolls.

Aleksandr I Egunov¹, Ayano Inaba², Simon Gree¹

¹Institut de Science des Matériaux de Mulhouse, UMR 7361, CNRS-Université de Haute-Alsace, 15, rue Jean Starcky, Mulhouse 68057, France.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|May 16, 2016

Summary

This study introduces a novel method for controlled macromolecule release using chitosan acetate fibers. Programmed drug delivery is achieved by patterning the fibers, enabling tunable release kinetics for biomedical applications.

Keywords:

ATR FTIR spectroscopy Chitosan Chronopharmacology Controlled release Fluoroscein isocyanate dextran Macromolecule Model drug

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Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

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Published on: August 19, 2015

Area of Science:

Biomaterials Science
Drug Delivery Systems
Polymer Chemistry

Background:

Controlled release systems are crucial for effective drug delivery.
Biocompatible materials offer advantages for in vivo applications.
Chitosan-based materials are widely explored for their versatility.

Purpose of the Study:

To develop a non-trivial time-programmed release strategy for water-soluble macromolecules.
To utilize self-scrolled chitosan acetate (CA) fibers for controlled release applications.
To investigate the influence of patterning on drug release kinetics.

Main Methods:

Fabrication of biocompatible micro-containers using self-scrolled chitosan acetate (CA) fibers encapsulated in a poly(dimethylsiloxane) matrix.
Programming the release pattern by depositing Fluoroscein isocyanate dextran (FID) on the inner surface of CA fibers.
Investigating mass transfer and macromolecule diffusion through the fiber's open extremity.
Utilizing a swelling front propagation model and a random walk model for Fick's law to simulate release kinetics.

Main Results:

Demonstrated time-programmed release of macromolecules from CA fibers.
Achieved tunable release kinetics by controlling the placement and patterning of FID.
Showcased pulsatile release kinetics with a few hours interval between impulses based on discrete patterning.
Successfully simulated release kinetics using a random walk model.

Conclusions:

Self-scrolled chitosan acetate fibers provide a viable platform for programmed macromolecule release.
Patterning of the polymer film prior to rolling enables precise control over drug release kinetics.
The developed system offers potential for advanced drug delivery applications requiring controlled and pulsatile release.