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Inverse association of total testosterone with central haemodynamics and left ventricular mass in hypertensive men

Charalambos Vlachopoulos1, Panagiota Pietri1, Nikolaos Ioakeimidis1

  • 1Hypertension Unit and Peripheral Vessels Units, 1st Cardiology Department, Hippokration Hospital, Athens Medical School, Athens, Greece.

Atherosclerosis
|May 16, 2016
PubMed

Insights

Low total testosterone (TT) in hypertensive men is independently linked to higher central blood pressure and left ventricular mass. This finding may help explain increased cardiovascular risk in men with low testosterone levels.

Area of Science:

  • Cardiovascular endocrinology
  • Hypertension research
  • Men's health

Background:

  • Low plasma testosterone is linked to increased cardiovascular event risk in hypertensive men.
  • Central blood pressure is a key determinant of left ventricular hypertrophy and cardiovascular mortality.
  • Understanding the relationship between testosterone and cardiovascular parameters in hypertension is crucial.

Purpose of the Study:

  • To investigate the association between total testosterone (TT) and central hemodynamics.
  • To assess the relationship between TT and left ventricular mass in hypertensive men.
  • To explore the role of TT in cardiovascular risk stratification in hypertensive males.

Main Methods:

  • Study included 134 hypertensive men and 60 normotensive controls.
  • Central hemodynamics (aortic systolic pressure, aortic pulse pressure, augmentation index) measured using pulse wave analysis.
  • Left ventricular mass calculated via echocardiography; plasma TT measured by enzyme immunoassay.

Main Results:

  • Significant inverse correlations found between TT and aortic systolic pressure, aortic pulse pressure, augmentation index, and left ventricular mass in hypertensive men.
  • Multivariate analysis confirmed independent inverse associations of TT with aortic pulse pressure, augmentation index, and left ventricular mass.
  • These associations remained significant even after adjusting for multiple cardiovascular risk factors and including normotensive subjects.

Conclusions:

  • Total testosterone is independently and inversely associated with central pulse pressure, wave reflections, and left ventricular mass in hypertensive men.
  • These findings suggest low testosterone may contribute to increased cardiovascular risk in hypertensive patients.
  • Further research is needed to determine if assessing central hemodynamics can improve risk stratification in hypertensive men with low testosterone.
Abstract

Keywords:
Arterial hypertensionCentral blood pressuresLeft ventricular massTotal testosteroneWave reflections

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