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Plasma Corin as a Predictor of Cardiovascular Events in Patients With Chronic Heart Failure
Xiang Zhou1, Jian-Chang Chen1, Ying Liu2
1Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Insights
Plasma corin is a valuable prognostic marker for major adverse cardiac events (MACE) in patients with chronic heart failure (CHF). Low corin levels predict worse outcomes, independent of traditional risk factors.
Area of Science:
- Cardiology
- Biomarker Discovery
- Prognostic Medicine
Background:
- Corin plays a critical role in regulating blood pressure and cardiac function.
- Accumulating evidence suggests corin's involvement in cardiovascular health.
Purpose of the Study:
- To determine the prognostic value of plasma corin in patients with chronic heart failure (CHF).
Main Methods:
- Prospective cohort study of 1,148 CHF patients.
- Exploration of the association between plasma corin levels and clinical prognosis.
- Multivariate Cox regression analysis was employed.
Main Results:
- Low plasma corin levels (<458 pg/ml) were associated with female sex, hypertension, increased NYHA functional class, elevated NT-proBNP, and reduced LVEF and eGFR.
- Plasma corin was an independent predictor of major adverse cardiac events (MACE), cardiovascular death, and heart failure rehospitalization.
- Low corin levels predicted MACE in patients regardless of NT-proBNP levels.
Conclusions:
- Plasma corin is a valuable prognostic marker for MACE in CHF patients.
- Corin's prognostic value is independent of established conventional risk factors.
- This finding supports corin's potential as a novel biomarker for risk stratification in CHF.
Objectives:
The aim of this study was to determine the prognostic value of plasma corin in patients with chronic heart failure (CHF).
Background:
In recent years, accumulating evidence has indicated that corin plays a critical role in regulating blood pressure and cardiac function.
Methods:
We enrolled 1,148 consecutive CHF patients in a prospective cohort study and explored the association between plasma corin levels and clinical prognosis using multivariate Cox regression analysis.
Results:
Patients with low corin levels (<458 pg/ml) were more likely to be women and to be hypertensive. Low corin was found to be associated with an increase in New York Heart Association (NYHA) functional class and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, and a decrease in left ventricular ejection fraction (LVEF) and the estimated glomerular filtration rate (eGFR). Multivariate Cox regression analysis suggested that log corin was an independent predictor of major adverse cardiac event(s) (MACE) (hazard ratio: 0.62; 95% confidence interval: 0.39 to 0.95), together with age, diabetes, NYHA functional class, LVEF, eGFR, and log NT-proBNP. In addition, log corin was also a significant predictor for cardiovascular death (p = 0.041) and heart failure rehospitalization (p = 0.015) after adjustment for clinical variables and established biomarkers of adverse prognosis. The Kaplan-Meier survival curves showed that low corin was a significant predictor of MACE in patients with NT-proBNP levels above and below the median.
Conclusions:
Our study demonstrates that plasma corin is a valuable prognostic marker of MACE in patients with CHF, independent of established conventional risk factors.
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