Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Wound hematoma: prophylaxis with topical thrombin.

W S Roberts1, D Cavanagh, V C Roberts

  • 1Department of Obstetrics and Gynecology, Tampa General Hospital, FL.

Southern Medical Journal
|May 1, 1989
PubMed
Summary

Topical thrombin irrigation did not significantly prevent wound hematomas in gynecologic surgery patients not receiving heparin. Minor hematomas were more frequent with saline, but the difference was not statistically significant.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Case of Myelitis Ending in Recovery.

Buffalo medical and surgical journal·2023
Same author

Association of clinical factors and recent anticancer therapy with COVID-19 severity among patients with cancer: a report from the COVID-19 and Cancer Consortium.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Supportive care in patients with cancer during the COVID-19 pandemic.

ESMO open·2021
Same author

Personalized cancer supportive care in COVID-19 era.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Overall survival and risk of second malignancies with cancer chemotherapy and G-CSF support.

Annals of oncology : official journal of the European Society for Medical Oncology·2018
Same author

Clinical prediction rules for mortality in patients with pulmonary embolism and cancer to guide outpatient management: a meta-analysis.

Journal of thrombosis and haemostasis : JTH·2017

Area of Science:

  • Surgical innovation
  • Gynecologic surgery
  • Wound healing

Background:

  • Wound complications, such as hematomas, can occur after abdominal surgery.
  • Topical hemostatic agents are explored to reduce surgical bleeding and associated complications.

Purpose of the Study:

  • To evaluate the efficacy of topical thrombin versus saline irrigation in preventing wound hematomas after midline laparotomy for gynecologic disease.

Main Methods:

  • A randomized controlled trial involving 123 patients undergoing elective exploratory laparotomy.
  • Patients received either saline or topical thrombin wound irrigation before incision closure.
  • Exclusion of patients receiving perioperative low-dose heparin therapy.

Main Results:

Related Experiment Videos

  • No significant difference in clinically significant wound hematomas or disruptions between the topical thrombin and saline groups.
  • Minor wound hematomas were more frequent in the saline group, nearing statistical significance.
  • No significant differences in preoperative or postoperative blood coagulation profiles were observed.

Conclusions:

  • Topical thrombin irrigation is likely not clinically beneficial for preventing wound hematomas in patients not on perioperative low-dose heparin.
  • Topical thrombin appears safe for application to open surgical wounds in this patient population.