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TOX expression in cutaneous B-cell lymphomas.

Anne M R Schrader1, Patty M Jansen2, Rein Willemze3

  • 1Department of Pathology, Leiden University Medical Center, P.O. box 9600, 2300 RC, Leiden, The Netherlands. a.m.r.schrader@lumc.nl.

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|May 16, 2016
PubMed
Summary

Thymocyte selection-associated high-mobility group box (TOX) is found in reactive and cancerous B-cells, including primary cutaneous follicle center lymphoma. TOX expression in B-cell lymphomas warrants further investigation.

Keywords:
Cutaneous B-cell lymphomaImmunohistochemistryPrimary cutaneous diffuse large B-cell lymphoma, leg typePrimary cutaneous follicle center lymphomaPrimary cutaneous marginal zone lymphomaTOX

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Area of Science:

  • Immunology
  • Oncology
  • Dermatology

Background:

  • Thymocyte selection-associated high-mobility group box (TOX) is known for its aberrant expression in cutaneous T-cell lymphomas.
  • Recent findings unexpectedly detected TOX expression in germinal center B-cells of reactive lymph nodes and tonsils.

Purpose of the Study:

  • To investigate TOX expression in cutaneous B-cell lymphomas.
  • To determine if TOX is present in neoplastic B-cells within skin biopsies.

Main Methods:

  • TOX immunohistochemistry was performed on skin biopsies from 44 patients with primary and secondary cutaneous B-cell proliferations.
  • Expression patterns were compared with BCL6, a germinal center B-cell marker.

Main Results:

  • TOX was expressed in reactive follicle center cells and neoplastic cells of primary cutaneous follicle center lymphoma (PCFCL) and systemic follicular lymphoma (FL).
  • TOX was also detected in a subset of BCL6-positive primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL,LT) and secondary cutaneous diffuse large B-cell lymphoma (DLBCL).
  • BCL6-negative PCDLBCL,LT showed minimal to no TOX expression.

Conclusions:

  • TOX is expressed in reactive and neoplastic germinal center B-cells.
  • TOX is present in a proportion of BCL6-positive cutaneous diffuse large B-cell lymphomas.
  • The functional role of TOX in B-cell malignancies requires further research.