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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
333
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Updated: Mar 21, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

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Obesity and osteoarthritis.

Kunal Kulkarni1, Timothy Karssiens1, Vijay Kumar2

  • 1East and North Hertfordshire NHS Trust, Lister Hospital, Stevenage, SG1 4AB, UK.

Maturitas
|May 16, 2016
PubMed
Summary

Obesity significantly increases the risk of knee osteoarthritis (OA) and the need for total knee arthroplasty (TKA). While surgery in obese patients presents challenges and risks, TKA can still improve function and quality of life.

Keywords:
ArthroplastyKneeObesityOsteoarthritisOutcomesReplacement

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Area of Science:

  • Orthopedics
  • Public Health
  • Metabolic Disorders

Background:

  • Osteoarthritis (OA) is a leading cause of disability worldwide, particularly affecting the knee joint.
  • Obesity is a primary modifiable risk factor for knee OA, with global obesity rates rapidly increasing.
  • Obese individuals (BMI > 30kg/m²) have a higher likelihood of requiring total knee arthroplasty (TKA).

Purpose of the Study:

  • To review the current understanding of the relationship between obesity and lower limb OA.
  • To evaluate the outcomes of TKA in patients with high Body Mass Index (BMI).
  • To assess the impact of obesity on surgical challenges and patient recovery after TKA.

Main Methods:

  • Systematic literature review of studies examining obesity, knee OA, and TKA outcomes.
  • Analysis of data on complication rates, functional recovery, and long-term implant survival in obese TKA patients.
  • Synthesis of evidence regarding the benefits and risks of TKA in individuals with high BMI.

Main Results:

  • Obesity is strongly linked to knee OA and increased TKA demand.
  • TKA in obese patients is technically more demanding, associated with higher short- to medium-term complication rates (e.g., infection, malalignment, longer hospital stays).
  • Despite potential challenges in recovery and long-term implant survival, obese patients can achieve significant improvements in quality of life, function, and satisfaction after TKA.

Conclusions:

  • Elevated BMI should not be an absolute contraindication for TKA.
  • Individual patient assessment is crucial for determining TKA candidacy in obese individuals.
  • While risks are higher, the benefits of TKA for function and quality of life remain relevant for obese patients with end-stage knee OA.