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Updated: Mar 21, 2026

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
Published on: September 7, 2018
Systems immunology: Beyond antibody titers
Raquel Cao1, Asuncion Mejias1, Octavio Ramilo1
1Division of Pediatric Infectious Diseases and Center for Vaccines and Immunity, Nationwide Children's Hospital, USA; The Ohio State University, USA.
Abstract:
Despite the evident success of currently available vaccines to prevent infectious diseases, we still lack a full understanding of the mechanisms by which vaccines induce protective immune responses. Systems immunology applies multifaceted analytical tools to better understand the immune responses to vaccines by deep characterization of the cellular components, regulatory pathways, antibody responses and immune gene profiles with the ultimate goal of identifying the complex cellular, genetic and regulatory factors and mechanisms that contribute to effective and protective immune responses.
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