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Updated: Mar 21, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Migraine: What Imaging Reveals
Catherine D Chong1, Todd J Schwedt2, David W Dodick2
1Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA. Chong.Catherine@mayo.edu.
Abstract:
Although migraine symptomatology is well-defined, our understanding of migraine pathophysiology is incomplete. Structural and functional brain imaging can contribute to a greater understanding of migraine pathophysiology. Recent neuroimaging studies demonstrate that migraine is associated with structural and functional alterations of brain regions commonly implicated in pain processing. This review summarizes recent brain structural and functional imaging findings in migraine and highlights those that are associated with characteristics such as the presence or absence of aura, associated cognitive dysfunction, sex-differences (male vs. female migraineurs), age, and disease burden.
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