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Association of growth and nutritional parameters with pulmonary function in cystic fibrosis: a literature review

Renan Marrichi Mauch1, Arthur Henrique Pezzo Kmit1, Fernando Augusto de Lima Marson1

  • 1Faculdade de Ciências Médicas, Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.

Revista Paulista De Pediatria : Orgao Oficial Da Sociedade De Pediatria De Sao Paulo
|May 17, 2016
PubMed

Insights

Growth and nutritional status are linked to lung function in pediatric cystic fibrosis patients. Early intervention can improve prognosis and life expectancy for these individuals.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Nutrition
  • Biostatistics

Background:

  • Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs, primarily the lungs.
  • Pulmonary function decline is a major cause of morbidity and mortality in CF.
  • Growth and nutritional status are critical indicators of health in pediatric CF patients.

Purpose of the Study:

  • To conduct a literature review on the association between growth and nutritional parameters and pulmonary function in pediatric cystic fibrosis.
  • To synthesize current evidence on how these factors influence lung health in young CF patients.

Main Methods:

  • Systematic literature search of databases (PubMed, Cochrane, Medline, Lilacs, Scielo) for articles published in the last 15 years.
  • Inclusion criteria focused on long-term associations of growth and nutrition with pulmonary disease in CF.
  • Excluded studies focusing solely on nutritional parameters or disease description.

Main Results:

  • Seven studies involving 12,455 patients were included in the review.
  • Six studies examined the relationship between growth parameters and lung function.
  • All seven studies reported a link between nutritional parameters and lung function.

Conclusions:

  • Pulmonary disease severity in CF, assessed by spirometry, correlates with impaired body growth and nutritional status.
  • Targeted interventions addressing growth and nutritional parameters may enhance prognosis and increase life expectancy in CF patients.
Abstract

Keywords:
CrescimentoCystic fibrosisFibrose císticaGrowthLung/pathophysiologyNutritionNutriçãoPulmão/fisiopatologia

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