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Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem

Tara Srinivasan1, Elaine Bich Than2, Pengcheng Bu1,3

  • 1Department of Biomedical Engineering, Cornell University, Ithaca, New York, 14853, USA.

Scientific Reports
|May 17, 2016
PubMed
Summary

NOTCH signaling controls intestinal stem cell (ISC) plasticity by regulating the balance between fast-cycling LGR5+ and slow-cycling BMI1+ cells. This pathway promotes interconversion and asymmetric division, crucial for tissue regeneration.

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