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Hemostatic markers in acute stroke.

W M Feinberg1, D C Bruck, M E Ring

  • 1Department of Neurology, University of Arizona Health Sciences Center, Tucson 85724.

Stroke
|May 1, 1989
PubMed
Summary
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This study shows that fibrin formation significantly exceeds fibrinolysis in acute ischemic stroke, with prolonged thrombin activity observed for up to 4 weeks. Fibrinolysis develops slowly after stroke.

Area of Science:

  • Biochemistry
  • Hematology
  • Neurology

Background:

  • Thrombosis and fibrinolysis are critical processes in acute ischemic stroke.
  • Understanding their time course is essential for effective treatment strategies.

Purpose of the Study:

  • To investigate the temporal dynamics of thrombosis and fibrinolysis markers following acute ischemic stroke.
  • To compare these markers in acute and chronic stroke patients.

Main Methods:

  • Measured concentrations of fibrinopeptide A (FpA), B-beta 1-42 peptide, B-beta 15-42 peptide, and crosslinked D-dimer (XDP).
  • Analyzed samples from 31 acute ischemic stroke patients and 13 chronic stroke patients at various time points.

Main Results:

  • Fibrinopeptide A (FpA) levels were significantly elevated in the first week post-stroke, declining over the first month.

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  • Crosslinked D-dimer (XDP) levels showed a slight elevation in the first week, increasing over the subsequent two weeks.
  • B-beta peptides (B-beta 1-42 and B-beta 15-42) were not elevated at any time point.
  • Elevated FpA in chronic stroke patients was not significant.

    • Conclusions:

    • Fibrin formation markedly exceeds endogenous fibrinolysis during the acute phase of ischemic stroke.
    • Endogenous fibrinolysis develops slowly after stroke.
    • Prolonged FpA elevation suggests sustained thrombin activity and fibrin formation for up to 4 weeks in some acute stroke patients.