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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Related Experiment Video

Updated: Mar 21, 2026

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
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Characterization of Large-Area SiPM Array for PET Applications.

Junwei Du1, Yongfeng Yang1, Xiaowei Bai1

  • 1Department of Biomedical Engineering, University of California, Davis, CA 95616 USA.

IEEE Transactions on Nuclear Science
|May 17, 2016
PubMed
Summary

This study evaluated a large-area silicon photomultiplier (SiPM) array for positron emission tomography (PET) applications. The SiPM array demonstrated excellent performance, resolving crystal pitches as small as 1.2 mm, making it suitable for high-resolution PET scanners.

Keywords:
InstrumentationNuclear medicinePETSilicon photomultiplier

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Area of Science:

  • Nuclear Instrumentation and Detectors
  • Medical Imaging Physics
  • Photon Detection Technology

Background:

  • Positron Emission Tomography (PET) requires high-performance photodetectors for precise imaging.
  • Silicon Photomultipliers (SiPMs) offer advantages in sensitivity and spatial resolution for PET systems.
  • Evaluating large-area SiPM arrays is crucial for advancing PET scanner design.

Purpose of the Study:

  • To assess the performance of an 8x8 SiPM array for PET applications.
  • To investigate the impact of crystal pitch size and operating conditions on SiPM array performance.
  • To determine the suitability of the SiPM array for high-resolution PET scanners.

Main Methods:

  • An 8x8 array of enhanced blue sensitivity SiPMs was fabricated and integrated with custom readout electronics.
  • Performance was evaluated using crystal arrays with varying pitch sizes (1.2 mm to 3.4 mm).
  • Measurements included flood histogram decoding, energy resolution, timing resolution, and saturation at different bias voltages and temperatures.

Main Results:

  • The best flood histogram quality was achieved at 28.0 V bias and 5 °C, resolving 1.2 mm crystal pitch.
  • No saturation was observed up to 29.5 V bias, indicating good light sharing.
  • Energy resolution ranged from 12.7% to 14.6%, and timing resolution from 1.58 ns to 2.50 ns at 5 °C.

Conclusions:

  • Superior performance (flood histogram, energy, and timing resolution) was observed at lower temperatures and larger crystal pitch sizes.
  • The large-area SiPM array demonstrates potential as a photodetector for high-resolution small-animal or human brain PET scanners.
  • The study confirms the viability of advanced SiPM technology for next-generation PET imaging systems.