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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Liver transplantation: Current status and challenges.

Caroline C Jadlowiec1, Timucin Taner1

  • 1Caroline C Jadlowiec, Timucin Taner, William J. von Liebig Transplantation Center, Division of Transplant Surgery, Department of Surgery, Mayo Clinic, Rochester, MN 55905, United States.

World Journal of Gastroenterology
|May 17, 2016
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Summary

Liver transplant advancements face organ shortages and long-term immunosuppression issues. Strategies like using donation after cardiac death (DCD) donors and perfusion techniques are being explored to improve outcomes.

Keywords:
Antibody-mediated rejectionDonation after cardiac deathMechanical perfusionRenal-sparing immunosuppression

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Area of Science:

  • Hepatology and Transplant Surgery

Background:

  • Liver transplantation has advanced significantly, yet faces challenges including organ scarcity and waitlist mortality.
  • Living donation boosts transplant numbers in Asia, but stagnates in Western countries, necessitating increased deceased donor utilization.

Purpose of the Study:

  • To address the challenges of organ shortage and suboptimal long-term outcomes in liver transplantation.
  • To explore the utility of donation after cardiac death (DCD) allografts and novel perfusion strategies.

Main Methods:

  • Increased utilization of liver allografts from donation after cardiac death (DCD) donors and extended criteria donors.
  • Development and application of mechanical perfusion strategies (hypothermic and normothermic) for liver allografts.
  • Investigating long-term outcomes and complications of immunosuppression in liver transplant recipients.

Main Results:

  • Mechanical perfusion strategies show potential for improving patient survival and allograft function.
  • Understanding pathophysiology of DCD liver allografts aids donor selection and management.
  • Long-term recipient outcomes remain limited by immunosuppression complications like infection, malignancy, and renal failure.

Conclusions:

  • Utilizing DCD donors and perfusion technologies offers promising avenues to mitigate organ shortage in liver transplantation.
  • Addressing long-term immunosuppression complications is critical for improving overall liver transplant recipient survival and graft longevity.