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Determination of unresolved heteronuclear scalar coupling constants by J(up)-HSQMBC
Simon Glanzer1, Olaf Kunert2, Klaus Zangger1
1Institute of Chemistry/Organic and Bioorganic Chemistry, University of Graz, Austria.
Abstract:
Long-range heteronuclear scalar coupling constants provide important structural information, which is necessary for obtaining stereospecific assignment or dihedral angle information. The measurement of small proton-carbon splittings is particularly difficult due to the low natural abundance of carbon-13 and the presence of homonuclear couplings of similar size. Here we present a real-time J-upscaled HSQMBC, which allows the measurement of heteronuclear coupling constants even if they are hidden in the signal linewidth of a regular spectrum.
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