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Updated: Mar 21, 2026

Reducing State Anxiety Using Working Memory Maintenance
Published on: July 19, 2017
A possible effect of methylphenidate on state anxiety: A single dose, placebo controlled, crossover study in a
Aviv Segev1, Hila Zahava Gvirts1, Kevin Strouse2
1Shalvata Mental Health Center, Hod Hasharon, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Abstract:
Methylphenidate affects state-anxiety in ADHD patients. The current study examines the effect of Methylphenidate on state-anxiety in healthy subjects. In a cross-over, randomized, controlled, double-blind study, 36 healthy subjects received either Methylphenidate or placebo. As a group, no change in state-anxiety was detected with Methylphenidate. However, participants reporting higher anxiety levels experienced a significant and specific state-anxiety reduction following Methylphenidate. Moreover, a strong negative correlation was found between the initial-level of anxiety and net-change in state-anxiety. These changes were unrelated to self-perceived attention levels. Our results point to the state-dependent effects of Methylphenidate on anxiety.
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