Choroidal Metastases From Cutaneous Melanoma

Area of Science:

• Ophthalmology
• Oncology
• Medical Retina

Background:

• Cutaneous malignant melanoma can metastasize hematogenously to the choroid.
• Ocular metastasis can present with visual disturbances and characteristic funduscopic findings.

Observation:

• A 92-year-old male with a history of melanoma presented with progressive blurry vision.
• Fundus examination revealed multiple elevated, pigmented choroidal lesions with subretinal fluid.
• Visual acuity was significantly reduced in the affected eye, with metamorphopsia noted.

Findings:

• The clinical presentation was consistent with hematogenous metastasis of cutaneous malignant melanoma to the choroid.
• Associated serous fluid in the macula led to metamorphopsia.

Implications:

• This case underscores the importance of considering ocular metastasis in patients with a history of melanoma presenting with visual changes.
• Early detection and management of choroidal metastasis are crucial for preserving vision.
• The patient was enrolled in a clinical trial investigating plasmid IL-12 combined with pembrolizumab.