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Published on: August 16, 2017
Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse
Jie Li1, Wei Xia1, Xueting Su1
1Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
Abstract:
In recent years, p53 was identified to regulate the expression of many miRNAs and was also regulated by miRNAs. In this paper, we found that miR-138 showed a pronounced increase after p53 activation in human non-small cell lung cancer (NSCLC) cells, which is mediated by p53 binding sites in the promoter region of its host gene, but this did not happen with rat and mouse cells. More interestingly, we found that p53 could be also regulated by miR-138 in mouse and rat cells, but not in the human NSCLC cells. Our results suggest the existence of species-specific differences of the regulations of miRNA against its targets and the regulations of miRNA itself by other proteins.
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