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Diastolic dysfunction and cardiac troponin I decrease in aging hearts.

B Pan1, Z W Xu1, Y Xu1

  • 1Heart Centre, Children's Hospital of Chongqing Medical University, Chongqing, PR China; Key Laboratory of Developmental Disease in Childhood (Chongqing Medical University), Ministry of Education, Chongqing, PR China; Key Laboratory of Pediatrics in Chongqing, PR China; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, PR China.

Archives of Biochemistry and Biophysics
|May 18, 2016
PubMed
Summary

Cardiac troponin I (cTnI) levels decrease with age, leading to diastolic dysfunction in older hearts. Epigenetic modifications, specifically histone acetylation, regulate cTnI expression and contribute to this age-related decline.

Keywords:
Diastolic dysfunctionEpigeneticsGene expressionHistone acetylationTroponin

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Area of Science:

  • Cardiovascular Biology
  • Molecular Cardiology
  • Aging Research

Background:

  • Cardiac troponin I (cTnI) is crucial for diastolic function.
  • Reduced cTnI expression is linked to cardiac diastolic dysfunction, prevalent in aging populations.
  • Understanding age-related changes in cTnI is vital for cardiovascular health.

Purpose of the Study:

  • To investigate the age-dependent changes in cardiac troponin I (cTnI) expression in mice.
  • To assess the relationship between cTnI levels and cardiac diastolic function in aging.
  • To explore the underlying epigenetic mechanisms, including DNA methylation and histone acetylation, affecting cTnI gene expression.

Main Methods:

  • Comparative analysis of cTnI expression levels in young adult (3 and 10 months) and older (18 months) mice hearts.
  • Assessment of cardiac function using Pressure-Volume (P-V) loop analysis and echocardiography.
  • Examination of DNA methylation and histone acetylation patterns near the cTnI gene promoter.

Main Results:

  • cTnI expression peaked in young adult hearts and significantly decreased in older hearts.
  • Older mice exhibited pronounced cardiac diastolic dysfunction.
  • Histone acetylation near the cTnI promoter was identified as a key regulator of cTnI expression during aging.

Conclusions:

  • Decreased cardiac troponin I (cTnI) levels in aging hearts are associated with diastolic dysfunction.
  • Epigenetic modifications, particularly histone acetylation, play a significant role in the age-related decline of cTnI expression.
  • These findings suggest a potential therapeutic target for age-related cardiac dysfunction.