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Related Experiment Videos

Comparative bioavailability of praziquantel tablets.

S Kaojarern1, S Nathakarnkikool, U Suvanakoot

  • 1Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

DICP : the Annals of Pharmacotherapy
|January 1, 1989
PubMed
Summary

Generic praziquantel tablets showed lower bioavailability due to poor disintegration and dissolution. This significantly impacts treatment efficacy, potentially leading to higher failure rates in praziquantel therapy.

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Area of Science:

  • Pharmacology
  • Pharmaceutical Sciences
  • Drug Bioavailability

Background:

  • Praziquantel is a crucial anthelmintic drug.
  • Ensuring consistent quality and bioavailability of generic praziquantel is vital for effective treatment.
  • Variations in pharmaceutical formulations can impact drug performance.

Purpose of the Study:

  • To evaluate the in vitro quality and in vivo bioavailability of different praziquantel tablet brands.
  • To compare generic praziquantel formulations against the original brand.
  • To assess the impact of formulation differences on praziquantel pharmacokinetics.

Main Methods:

  • In vitro disintegration testing of six praziquantel brands against British Pharmacopoeia standards.
  • A four-brand comparative bioavailability study in eight healthy volunteers using a crossover design.

Related Experiment Videos

  • Quantification of serum praziquantel levels via high-performance liquid chromatography (HPLC).

    • Main Results:

    • One of six brands failed disintegration time specifications.
    • Significant pharmacokinetic differences (p < 0.05) were observed between generic and original praziquantel brands.
    • Relative bioavailability of generic formulations ranged from 69.86% to 91.25% compared to the original brand.

    Conclusions:

    • Substandard disintegration and dissolution in some generic praziquantel tablets lead to reduced bioavailability.
    • A potential 30% reduction in bioavailability may result in unacceptable treatment failure rates.
    • Quality control of generic praziquantel is critical to ensure therapeutic efficacy.