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Equal sensitivity of the new generation QuantiFERON-TB Gold plus in direct comparison with the previous test version

H Hoffmann1, K Avsar2, R Göres2

  • 1Synlab MVZ Gauting, Zweigniederlassung der synlab MVZ Augsburg GmbH, Gauting, Germany; IML red GmbH, Institute of Microbiology and Laboratory Medicine, WHO Supranational Reference Laboratory of Tuberculosis, Gauting, Germany.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|May 18, 2016
PubMed

QuantiFERON-TB Gold IT analyses interferon-γ release from CD4(+) T cells after stimulation with specific tuberculosis (TB) antigens. Its sensitivity is approximately 80% for active TB. A new test generation (QFTGplus) also analyses the response of CD8(+) T cells. We investigated both test generations in a direct head-to-head comparison in a German pulmonary hospital. Sensitivity rates for active TB were identical, no matter whether diagnosis was bacteriologically confirmed or not.

Keywords:
Interferon-γ release assayQuantiFERON-TB Gold in tubeQuantiFERON-TB Gold plusSensitivityTuberculosis

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