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Updated: Mar 21, 2026

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
Published on: April 9, 2012
Equal sensitivity of the new generation QuantiFERON-TB Gold plus in direct comparison with the previous test version
H Hoffmann1, K Avsar2, R Göres2
1Synlab MVZ Gauting, Zweigniederlassung der synlab MVZ Augsburg GmbH, Gauting, Germany; IML red GmbH, Institute of Microbiology and Laboratory Medicine, WHO Supranational Reference Laboratory of Tuberculosis, Gauting, Germany.
Abstract:
QuantiFERON-TB Gold IT analyses interferon-γ release from CD4(+) T cells after stimulation with specific tuberculosis (TB) antigens. Its sensitivity is approximately 80% for active TB. A new test generation (QFTGplus) also analyses the response of CD8(+) T cells. We investigated both test generations in a direct head-to-head comparison in a German pulmonary hospital. Sensitivity rates for active TB were identical, no matter whether diagnosis was bacteriologically confirmed or not.
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