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Related Concept Videos

Hepatitis01:25

Hepatitis

7
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
7
Vaccine Production01:23

Vaccine Production

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Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
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Infectious Diseases and Their Occurrence01:28

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Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable...
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Arboviral Encephalitis01:25

Arboviral Encephalitis

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Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
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Hepatitis E virus: Current epidemiology and vaccine.

Xing Wu1, Pan Chen1, Huijuan Lin2

  • 1a National Institutes for Food and Drug Control , Beijing , PR China.

Human Vaccines & Immunotherapeutics
|May 18, 2016
PubMed
Summary

Hepatitis E virus (HEV) infection is a global health concern, particularly for pregnant women. Hecolin®, a licensed HEV vaccine, shows promise but requires further evaluation and international regulatory approval for widespread use.

Keywords:
Hecolin®Hepatitis E virusepidemiologyquality controlvaccine

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Area of Science:

  • * Virology
  • * Vaccinology
  • * Public Health

Background:

  • * Hepatitis E virus (HEV) infections are prevalent in Asia and Africa, posing significant risks, especially to pregnant women.
  • * Hecolin® is the sole licensed vaccine against HEV, developed by Xiamen Innovax Biotech Co., Ltd., with demonstrated antigenicity and efficacy.

Purpose of the Study:

  • * To review the characteristics and potential of Hecolin® for global Hepatitis E control.
  • * To identify and discuss barriers to the large-scale application of Hecolin®.

Main Methods:

  • * Comprehensive review of existing data on Hecolin®.
  • * Analysis of clinical trial outcomes and manufacturing capabilities.
  • * Examination of regulatory and quality control requirements for international adoption.

Main Results:

  • * Hecolin® exhibits favorable antigenicity, physicochemical properties, and clinical trial efficacy.
  • * Significant obstacles remain, including the need for further safety and efficacy assessments in at-risk populations.
  • * Obtaining World Health Organization (WHO) prequalification and non-China licensing are critical for global promotion.

Conclusions:

  • * Hecolin® is a promising vaccine for HEV control, but further research and regulatory steps are essential.
  • * Enhanced safety and efficacy evaluations in vulnerable groups are necessary.
  • * International cooperation and regulatory harmonization are key to Hecolin®'s global accessibility and impact on Hepatitis E prevention.