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Ranitidine-induced chest pain.

L A Shimp1, M A Smith, D W Wahr

  • 1College of Pharmacy, Ann Arbor, MI 48109.

DICP : the Annals of Pharmacotherapy
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

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Ranitidine, a common heartburn medication, may cause chest pain in some individuals. This case report highlights a potential cardiac side effect of H2-blockers, warranting further investigation.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Ranitidine is a histamine H2-receptor antagonist commonly used to treat acid reflux and ulcers.
  • H2-receptors are known to be present in cardiovascular tissues, suggesting a potential for cardiac effects.

Observation:

  • A 45-year-old woman with no prior cardiac history reported experiencing substernal chest pain twice after taking ranitidine.
  • The chest pain was described as dull, pounding, and located left of midline, lasting approximately one hour on both occasions.

Findings:

  • While many studies show no significant cardiac impact from ranitidine, case reports suggest potential cardiovascular effects.
  • This is the first reported instance of chest pain specifically associated with H2-blocker ingestion, though related effects like bradycardia and hypotension could explain the symptom.

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Implications:

  • This case suggests a possible, albeit rare, adverse cardiac event associated with ranitidine use.
  • Further research is needed to elucidate the mechanisms and prevalence of ranitidine-induced chest pain and its relation to H2-receptor activity in the heart.