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Cyclodextrin type dependent host-guest interaction mode with phthalocyanine and their influence on photodynamic
1College of Chemistry and Materials Science, Analysis and Testing Centre, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
Abstract:
Three host-guest complexes of phthalocyanines (Pc) with α-, β- or γ-cyclodextrins (CDs) were prepared and their interaction modes, reactive oxygen species (ROSs) generation ability and in vitro anticancer activities were studied and compared. After forming complex with CD, the aggregation degree of Pc was greatly decreased and the water solubility and photodynamic activity was sharply increased. Computer modeling results indicated that the interaction modes between Pc and CDs were varied with different kinds of CD. Especially, the complex of Pc and β-CD has superior stability, ROSs generation ability, and anticancer activity to other complexes.
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