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[Eales' disease].

M-H Errera1, A Pratas1, P Goldschmidt1

  • 1Inserm-DHOS CIC 1423, service d'ophtalmologie IV, médecine interne, laboratoire, université Pierre-et-Marie-Curie-Paris 6, centre hospitalier national des Quinze-Vingts, DHU SightRestore, 28, rue de Charenton, 75012 Paris, France.

Journal Francais D'Ophtalmologie
|May 18, 2016
PubMed
Summary
This summary is machine-generated.

Eales disease, a cause of recurrent vitreous hemorrhages in young adults, involves ischemic retinal vasculitis. Early detection and management are crucial to prevent vision loss from complications like retinal detachment.

Keywords:
BevacizumabBévacizumabDécollement de la rétineEales diseaseIdiopathic retinal periphlebitisMaladie de EalesPars plana vitrectomyPériphlébite rétinienne idiopathiqueRetinal detachmentTuberculoseTuberculosisVitrectomie

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Area of Science:

  • Ophthalmology
  • Retinal Vascular Diseases
  • Immunology

Background:

  • Eales disease, first described in 1880, affects young adults with recurrent vitreous hemorrhages.
  • It is characterized by ischemic retinal vasculitis, predominantly in the peripheral retina, with a higher prevalence in South Asia.
  • The exact etiology remains unknown but may involve immune sensitivity to Mycobacterium tuberculosis antigens.

Purpose of the Study:

  • To summarize the clinical presentation, pathogenesis, and management of Eales disease.
  • To highlight the potential for vision-threatening complications.
  • To emphasize the need for regular follow-up due to the variable natural history.

Main Methods:

  • Review of historical and clinical literature on Eales disease.
  • Analysis of the pathological mechanisms involving retinal ischemia and neovascularization.
  • Summary of current treatment strategies based on disease stage.

Main Results:

  • Eales disease involves retinal periphlebitis, capillary ischemia, proliferative retinopathy, and neovascularization.
  • Recurrent vitreous hemorrhages and tractional retinal detachment are common, potentially leading to blindness.
  • Disease progression can be bilateral, necessitating consistent monitoring.

Conclusions:

  • Eales disease is a significant cause of vision impairment in young adults due to retinal vascular complications.
  • Management requires a tailored approach, including observation, surgical interventions (vitrectomy), anti-VEGF therapy, corticosteroids, and laser photocoagulation.
  • Further research into the etiology and standardized treatment protocols is warranted.