Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Lipogenesis, aging and hormonal regulation].

F Rassoul1, C Klein, V Richter

  • 1Institut für Klinische Chemie und Laboratoriumsdiagnostik Bereich Medizin der Karl-Marx-Universität Leipzig.

Zeitschrift Fur Gerontologie
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease.

The open neuroimaging journal·2009
Same author

Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology.

Experimental neurology·2009
Same author

Primary focal dystonia: evidence for distinct neuropsychiatric and personality profiles.

Journal of neurology, neurosurgery, and psychiatry·2009
Same author

Imaging the impact of genes on Parkinson's disease.

Neuroscience·2009
Same author

The D216H variant in the DYT1 gene: a susceptibility factor for dystonia in familial cases?

Neurology·2009
Same author

Somatosensory processing in a German family with PINK1 mutations: its potential role in Parkinson disease.

Journal of neurology, neurosurgery, and psychiatry·2009

Thyroid hormones impact fatty acid synthesis and lipogenic enzyme activity, with age influencing these effects in rats. Older rats showed impaired responses in the liver but not adipose tissue.

Area of Science:

  • Endocrinology and Metabolism
  • Molecular Biology
  • Biochemistry

Context:

  • Thyroid hormones are crucial regulators of lipid metabolism.
  • Age-related changes can alter hormonal responses and metabolic pathways.
  • Hepatic and adipose tissues exhibit distinct metabolic functions.

Purpose:

  • To investigate the age-dependent effects of thyroid hormones on fatty acid synthesis and lipogenic enzyme activity in rat liver and adipose tissue.
  • To compare the responses of young (3-month-old) and aged (18-month-old) Wistar rats to varying thyroid function.

Summary:

  • Thyroid hormones stimulate hepatic fatty acid synthesis and lipogenic enzyme activity, with some age-related differences observed.
  • Older rats exhibited impaired malic enzyme activity stimulation under hyperthyroidism and reduced fatty acid synthesis velocity.

Related Experiment Videos

  • Adipose tissue lipogenic enzyme activities were lower in older rats, with no observed effect of thyroid hormones in either age group.

    • Impact:

    • This study highlights age-specific alterations in thyroid hormone regulation of lipid metabolism.
    • Findings contribute to understanding metabolic changes associated with aging and thyroid dysfunction.
    • Provides insights into tissue-specific responses to hormonal changes in aging mammals.