Flow rates through intravenous access devices: an in vitro study
Related Experiment Video
Updated: Mar 21, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
Saleem I Khoyratty1, Pushpaj R Gajendragadkar2, Kiran Polisetty1
1National Women's Hospital, Auckland City Hospital, Auckland, New Zealand.
Study Objective:
Fluid administration using intravenous (IV) access devices is required in many settings. There are a lack of quantitative data comparing traditional cannulas and modern access devices. We aimed to investigate flow rates through modern intravenous access devices using an in vitro system.
Design:
This is an experimental study.
Setting And Measurements:
Rates of flow of intravenous fluids (crystalloid and colloid) were measured through various access devices using a uroflowmeter. Standardized conditions and repeat measurements ensured validity. Fluid was administered with or without the addition of a pressure bag and needle-free valve.
Main Results:
Increasing the size of cannulas improved flow. Fourteen-gauge cannulas had significantly higher mean flow rates compared to 14G central venous lines in all conditions (136% higher with no pressure bag/valve; 95% CI, +130% to +152%; P < .001). Both the emergency infusion device and rapid infusion catheter produced significantly increased mean flows compared to a 14G cannula (12% higher for emergency infusion catheter; 95% CI, +7% to +15%; P = .008, and 15% higher for rapid infusion catheter; 95% CI, +12% to +21%; P = .004). The needle-free valve significantly impaired flow on 16G and wider IV access devices (36% lower with no pressure bag using 14G cannula; 95% CI, -29% to -46%; P = .003), but flow reductions in narrower IV access were insignificant. Pressure bags significantly improved flow in all devices, in all combinations.
Conclusions:
Flow rates in IV devices can be maximized by pressure bag use and removal of needle-free valves. The rapid infusion catheter and emergency infusion catheter allow some increase in flow over a 14G cannula. Familiarity with varying flow rates across IV access devices could better inform clinical decisions.
More Related Videos
08:44An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices
Published on: August 21, 2020
07:30In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
Published on: November 3, 2015
Related Concept Videos
In Vitro Drug Dissolution: Compendial Testing Models II
One-Compartment Model: IV Infusion
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
In Vitro Drug Dissolution: Compendial Testing Models I
Drug Product Performance: In Vitro–In Vivo Correlation
One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
Two-Compartment Open Model: IV Infusion
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...