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Effect of maternal and neonatal factors on cord blood thyroid stimulating hormone

Sheetal G Lakshminarayana1, Nidhish P Sadanandan1, A K Mehaboob2

  • 1Department of Physiology, MES Medical College, Perinthalmanna, Malappuram, Kerala, India.

Indian Journal of Endocrinology and Metabolism
|May 18, 2016
PubMed

Insights

Congenital hypothyroidism (CH) screening using cord blood Thyroid Stimulating Hormone (CBTSH) is effective. Perinatal factors significantly influence CBTSH levels, impacting diagnosis and management in newborns.

Area of Science:

  • Neonatal screening
  • Endocrinology
  • Public Health

Background:

  • Congenital hypothyroidism (CH) is a primary preventable cause of intellectual disability in children.
  • Cord blood Thyroid Stimulating Hormone (CBTSH) is a validated screening method for CH.

Purpose of the Study:

  • To investigate CBTSH levels in neonates at a tertiary care center.
  • To analyze the impact of maternal and neonatal factors on CBTSH levels.

Main Methods:

  • A cross-sectional retrospective study of 979 neonates.
  • CBTSH levels measured via electrochemiluminescence immunoassay.
  • Levothyroxine initiated for abnormal levels, followed by reassessment.

Main Results:

  • Mean CBTSH was 7.82 μIU/mL; 4.39% had levels >16.10 μIU/mL and 1.02% had levels <1.0 μIU/mL.
  • Elevated CBTSH associated with assisted delivery, perinatal stress, and low Apgar scores.
  • Confirmed CH prevalence of approximately 3 in 1000 live births.

Conclusions:

  • CBTSH screening is a practical, non-invasive method for CH detection.
  • Mode of delivery and perinatal stress significantly affect CBTSH levels.
  • A recall rate of 5.41% is feasible for CH screening programs.
Abstract

Keywords:
Cord blood thyroid stimulating hormonecongenital hypothyroidismnewborn screening

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